COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 844
Case Study 2: Behavioral Issues in a Child
A 9-year-old male presents with attention difficulties, irritability, and
oppositional behavior. OAT shows markedly elevated HPHPA,
4-cresol, and low HVA and VMA. Interpretation: Clostridia
overgrowth producing toxic metabolites affecting
neurotransmitter function. Treatment plan: Targeted antimicrobials
for Clostridia, probiotics, nutrient support for neurotransmitter
production. Outcome: Significant behavioral improvement after
addressing gut dysbiosis.
Case Study 3: Treatment-Resistant Depression
A 35-year-old male with depression unresponsive to multiple
medications. OAT reveals low 5-HIAA, elevated quinolinic acid,
and markers of oxidative stress. Interpretation: Serotonin
deficiency with inflammation-driven tryptophan diversion to the
kynurenine pathway. Treatment plan: Anti-inflammatory protocol,
5-HTP with cofactors, glutathione support. Outcome: Substantial
mood improvement and eventual medication reduction.
Limitations and Considerations in Organic Acids Testing
Timing and Collection Variables
Diurnal variations in some organic acids Impact of recent diet on
certain markers Proper collection procedures critical for accurate
results
Interpretation Challenges
Need to correlate with clinical presentation Consideration of
medication effects on certain markers Variations in reference
ranges between laboratories
Complementary Testing Often Needed
OAT provides metabolic clues that may require confirmation Some
conditions require additional specialized testing Important to
integrate findings with complete clinical picture
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