COMPENDIUM ON FUNCTIONAL MEDICINE - Flipbook - Page 893
Predictor of Oxidative Stress
HbA1c serves as an indirect marker of oxidative stress, as glycation
processes directly contribute to free radical generation and
cellular damage [87].
Cognitive Function Indicator
Research has established strong correlations between HbA1c
levels and cognitive performance, with even mild elevations
associated with decreased executive function [88].
Inflammatory Mediator
Elevated HbA1c is directly linked to increased systemic
inflammation through advanced glycation end products (AGEs)
that trigger inflammatory cascades [89].
Mitochondrial Function Assessment
Higher HbA1c values indicate potential mitochondrial dysfunction,
as proper glucose metabolism depends on optimal mitochondrial
activity [90].
Monitoring Protocol and Interpretation
For comprehensive metabolic assessment, HbA1c should be
measured:
● At baseline for all patients
● Every 3 months when actively treating insulin resistance or
diabetes
● Every 6 months for patients with previous borderline results
● Annually for maintenance monitoring
HbA1c should always be interpreted alongside fasting insulin,
fasting glucose, and potentially HOMA-IR calculations for a
complete metabolic picture [91, 92].
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